Crestor, manufactured and marketed by AstraZeneca, is one of many cholesterol reducing drugs called "statins." Statins, combined with a low-cholesterol diet and exercise program, are prescribed topatients who have experienced difficulty lowering cholesterol with diet and exercise alone. The drug works by helping to lower total cholesterol and triglycerides in the patient's blood, while increasing the amount of HDL, or "good cholesterol," in the bloodstream. Some patients taking Crestor have suffered severe side effects, including kidney failure caused by rhabdomyolysis (muscle damage), which can be fatal. Patients experiencing muscle pain, weakness, tenderness, fever, dark urine, nausea, or vomiting should consult their doctor immediately.